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Publication
PubMed ID28093845Published Date2017-02-28JournalStatistics in medicine, 2017-02-28, Volume 36
Abstract not available
Clinical Trial
Clinical Trial IDNCT03049358Start Date2017-03-01Completion Date2020-03-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
This randomized phase I trial studies how well olfactory training works in improving sense of smell after radiation therapy in patients with paranasal sinus or nasopharyngeal cancer. Olfactory training may improve smell function after radiation therapy in patients with paranasal sinus or nasopharyngeal cancer.
Clinical Trial
Clinical Trial IDNCT02991807Start Date2017-03-01Completion Date2019-06-01PhasePhase 1/Phase 2Study TypeInterventionalStatusNot yet recruiting
Phosphatase and TENsin homolog (PTEN) gene germline mutations are associated with a spectrum of clinical manifestations characterized by neurocognitive deficits, intellectual disability, autism symptomatology, skin lesions, macrocephaly, hamartomatous overgrowth of tissues, and an increased risk of cancers. Investigators are conducting research to evaluate the potential safety and efficacy of RAD001 (everolimus) in this patient population, and the potential neurocognitive benefits from treatm…
Clinical Trial
Clinical Trial IDNCT02969707Start Date2017-03-01Completion Date2021-03-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The investigators plan to use functional neuroimaging (fMRI) to understand the brain systems affected when hypnosis and hypnotic analgesia are augmented with repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation to 100 people with fibromyalgia, a chronic pain condition. The investigators will measure the effect of rTMS- augmentation on the brain networks underlying hypnotizability, as well as the effect of rTMS-augmentation on hypnotic analgesia network…
Clinical Trial
Clinical Trial IDNCT03048890Start Date2017-03-01Completion Date2018-10-01PhaseN/AStudy TypeObservationalStatusNot yet recruiting
VascTrac is a mobile medical application that tracks users' physical activity levels in order to predict endovascular failure of patients with Peripheral Artery Disease.
Clinical Trial
Clinical Trial IDNCT03045328Start Date2017-03-01Completion Date2021-03-01PhasePhase 1/Phase 2Study TypeInterventionalStatusNot yet recruiting
This phase I/II trial studies the side effects and best dose of venetoclax when given together with ibrutinib and to see how well they work in treating patients with chronic lymphocytic leukemia or small lymphocytic lymphoma that has come back or does not respond to treatment. Venetoclax and ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Publication
PubMed ID27842456Published Date2017-03-01JournalFuture oncology (London, England), 2017-03-01, Volume 13
To provide a multi-institutional description of current practices of stereotactic body radiotherapy (SBRT) for head and neck cancer.15 international institutions with significant experience in head and neck SBRT were asked to complete a questionnaire covering clinical and technical factors.SBRT is used 10-100% of the time for recurrent primary head and neck cancer, and 0-10% of the time in newly diagnosed disease. Five centers use a constraint for primary disease of 3-5 cm and 25-30 cc. Nine …
Publication
PubMed ID27770562Published Date2017-03-01JournalJournal of biomedical materials research. Part A, 2017-03-01, Volume 105
Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with median survival of 12 months. To improve clinical outcomes, it is critical to develop in vitro models that support GBM proliferation and invasion for deciphering tumor progression and screening drug candidates. A key hallmark of GBM cells is their extreme invasiveness, a process mediated by matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix. We recently reported the development o…
Publication
PubMed ID28017481Published Date2017-03-01JournalNeurobiology of aging, 2017-03-01, Volume 51
We investigated a CAG trinucleotide repeat expansion in the ATXN2 gene in amyotrophic lateral sclerosis (ALS). Two new case-control studies, a British dataset of 1474 ALS cases and 567 controls, and a Dutch dataset of 1328 ALS cases and 691 controls were analyzed. In addition, to increase power, we systematically searched PubMed for case-control studies published after 1 August 2010 that investigated the association between ATXN2 intermediate repeats and ALS. We conducted a meta-analysis of t…
Publication
PubMed ID27810415Published Date2017-03-01JournalJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2017-03-01, Volume 37
The ARUBA trial (2014) concluded that medical management alone is superior to medical management plus interventional therapy for the treatment of unruptured brain arteriovenous malformations (bAVMs). This sparked considerable controversy among involved healthcare providers. Here, we evaluated the impact of ARUBA on the volume, type, and treatment modality of bAVMs referred to a large tertiary care center. This was achieved by conducting a retrospective review of a prospectively maintained dat…