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Clinical Trial
Clinical Trial IDNCT03037983Start Date2017-04-01Completion Date2019-04-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rTMS) is effective in remediating cognitive deficits while also improving functionality in Veterans with schizophrenia.
Publication
PubMed ID28040700Published Date2017-04-01JournalJournal of the National Cancer Institute, 2017-04-01, Volume 109
The National Clinical Trials Network lymphoid malignancies Clinical Trials Planning Meeting (CTPM) occurred in November of 2014. The scope of the CTPM was to prioritize across the lymphoid tumors clinically significant questions and to foster strategies leading to biologically informed and potentially practice changing clinical trials. This review from the Hodgkin lymphoma (HL) subcommittee of the CTPM discusses the ongoing clinical challenges in HL, outlines the current standard of care for …
Publication
PubMed ID27167683Published Date2017-04-01JournalJournal of sports sciences, 2017-04-01, Volume 35
The primary study objective was to identify determinants of short-term recovery from a 161-km ultramarathon. Participants completed 400 m runs at maximum speed before the race and on days 3 and 5 post-race, provided a post-race blood sample for plasma creatine kinase (CK) concentration, and provided lower body muscle pain and soreness ratings (soreness, 10-point scale) and overall muscular fatigue scores (fatigue, 100-point scale) pre-race and for 7 days post-race. Among 72 race finishers, so…
Publication
PubMed ID27981827Published Date2017-04-01JournalMinerva chirurgica, 2017-04-01, Volume 72
Obesity has been on the rise globally and more people are now clinically obese than ever before in the US. This issue has a significant impact on both health and cost to healthcare systems. Bariatric surgery is efficacious in treatment of obesity but only in late stages of the disease, and there is a requirement for less invasive techniques/devices to treat obesity at earlier stages. Currently a number of these are either in clinical trials or have recently been approved by the Food and Drug …
Publication
PubMed ID28138065Published Date2017-03-19JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017-03-19, Volume 372
Viral internal ribosome entry sites (IRESs) are unique RNA elements, which use stable and dynamic RNA structures to recruit ribosomes and drive protein synthesis. IRESs overcome the high complexity of the canonical eukaryotic translation initiation pathway, often functioning with a limited set of eukaryotic initiation factors. The simplest types of IRESs are typified by the cricket paralysis virus intergenic region (CrPV IGR) and hepatitis C virus (HCV) IRESs, both of which independently form…
Publication
PubMed ID28093557Published Date2017-03-05JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017-03-05, Volume 372
We review a body of theoretical and experimental research on Hebbian and homeostatic plasticity, starting from a puzzling observation: while homeostasis of synapses found in experiments is a slow compensatory process, most mathematical models of synaptic plasticity use rapid compensatory processes (RCPs). Even worse, with the slow homeostatic plasticity reported in experiments, simulations of existing plasticity models cannot maintain network stability unless further control mechanisms are im…
Publication
PubMed ID28093552Published Date2017-03-05JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017-03-05, Volume 372
We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of…
Publication
PubMed ID28093549Published Date2017-03-05JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017-03-05, Volume 372
Hebbian and homeostatic plasticity are two major forms of plasticity in the nervous system: Hebbian plasticity provides a synaptic basis for associative learning, whereas homeostatic plasticity serves to stabilize network activity. While achieving seemingly very different goals, these two types of plasticity interact functionally through overlapping elements in their respective mechanisms. Here, we review studies conducted in the mammalian central nervous system, summarize known circuit and m…
Publication
PubMed ID27842456Published Date2017-03-01JournalFuture oncology (London, England), 2017-03-01, Volume 13
To provide a multi-institutional description of current practices of stereotactic body radiotherapy (SBRT) for head and neck cancer.15 international institutions with significant experience in head and neck SBRT were asked to complete a questionnaire covering clinical and technical factors.SBRT is used 10-100% of the time for recurrent primary head and neck cancer, and 0-10% of the time in newly diagnosed disease. Five centers use a constraint for primary disease of 3-5 cm and 25-30 cc. Nine …
Publication
PubMed ID27770562Published Date2017-03-01JournalJournal of biomedical materials research. Part A, 2017-03-01, Volume 105
Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with median survival of 12 months. To improve clinical outcomes, it is critical to develop in vitro models that support GBM proliferation and invasion for deciphering tumor progression and screening drug candidates. A key hallmark of GBM cells is their extreme invasiveness, a process mediated by matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix. We recently reported the development o…