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Research Grant
Project Number5F30CA165873-02Funding AgencyNIHEffective Date2013-04-01Expiration Date2013-09-30Funding Amount$23,307
DESCRIPTION (provided by applicant): Ewing's sarcoma is an aggressive pediatric cancer of the bone and soft tissue. Patients that present with metastasis and patients who relapse have especially poor outcomes from this disease. Ewing's sarcoma is driven by a chromosomal translocation that produces the EWS/Fli1 fusion protein. We have identified the developmental protein, Eya3, as a downstream target of EWS/Fli1. Eya3 is important for DNA repair and is also found as part of a bipartite transcr…
Research Grant
Project Number1F30CA165873-01Funding AgencyNIHEffective Date2012-04-01Expiration Date2013-03-31Funding Amount$28,126
DESCRIPTION (provided by applicant): Ewing's sarcoma is an aggressive pediatric cancer of the bone and soft tissue. Patients that present with metastasis and patients who relapse have especially poor outcomes from this disease. Ewing's sarcoma is driven by a chromosomal translocation that produces the EWS/Fli1 fusion protein. We have identified the developmental protein, Eya3, as a downstream target of EWS/Fli1. Eya3 is important for DNA repair and is also found as part of a bipartite transcr…