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Clinical Trial
Clinical Trial IDNCT02885727Start Date2017-05-01Completion Date2022-12-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
Research Hypothesis: The combination of ionizing radiation and immunotherapy (durvalumab) is well tolerated and stimulates a clinically significant pancreas-cancer specific immune response. The primary objective will be to evaluate whether the combination of RT and durvalumab can improve median PFS compared to chemotherapy historical control data in metastatic pancreas cancer patients who have progressed through first-line chemotherapy. The primary intent of RT in this study is to augment a p…
Clinical Trial
Clinical Trial IDNCT03089398Start Date2017-05-01Completion Date2024-03-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The purpose of the study is to learn which treatment option is better for patients who have multi-vessel coronary artery disease (blockages in more than one vessel supplying blood to the heart muscle). The treatment options this study will compare are: (1) Hybrid Coronary Revascularization [HCR] (a combination of surgery and catheter procedures to open up clogged heart arteries) and (2) Percutaneous Coronary Intervention [PCI] (catheter procedures alone to open up clogged heart arteries). The…
Clinical Trial
Clinical Trial IDNCT03116529Start Date2017-05-01Completion Date2022-05-01PhasePhase 1/Phase 2Study TypeInterventionalStatusNot yet recruiting
Chemotherapy is controversial for soft tissue sarcoma that has not yet metastasized. Surgery and radiation are effective for local control, but there are no highly effective interventions to prevent metastatic spread of soft tissue sarcoma. Immunotherapy has shown promise in other types of cancer. Combining two types of immunotherapy agents with preoperative radiation may help the immune system recognize the sarcoma and stimulate an anti-tumor immune response.
Clinical Trial
Clinical Trial IDNCT02704637Start Date2017-05-01Completion Date2018-12-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
HeadSense (HS)-1000 device, a proprietary non-invasive brain monitor, is expected to safely and accurately monitor physiological signs of the brain with minimal discomfort to patients, providing information about normal or abnormal brain-related conditions and providing decision-making support for physicians. The investigators hypothesize that the HS-1000 is capable of detecting vasospasm using the raw acoustic data derived from the noninvasive procedure.
Clinical Trial
Clinical Trial IDNCT03066050Start Date2017-05-01Completion Date0031-12-01PhaseN/AStudy TypeObservationalStatusNot yet recruiting
This study is a continuation of two previous studies --- the Severe Ischemic Mitral Regurgitation (SMR) Trial (NCT00807040) and the Moderate Ischemic Mitral regurgitation (MMR) Trial (NCT00806988) --- to learn more about patients' health 5-10 years after their mitral valve surgeries. The investigators will collect long-term health information on SMR and MMR trial participants using electronic medical records, patient and/or family input, public records, and healthcare- and vital status-relate…
Clinical Trial
Clinical Trial IDNCT03111277Start Date2017-05-01Completion Date2021-05-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Neuropathic pain is often a result of direct diseases of peripheral or central nervous system with an estimated prevalence of 8% of adults and this pain is associated with significant consequences because of longer symptom duration and severity than many of the other pain syndromes. Functional brain imaging has revealed that many regions of the brain are engaged by painful events, but specific areas such as the thalamus have been markedly implicated. The purpose of this study is to determine …
Clinical Trial
Clinical Trial IDNCT02695680Start Date2017-05-01Completion Date2022-12-01PhaseN/AStudy TypeObservationalStatusNot yet recruiting
Real-time optical surface monitoring data will be acquired from 44 human patients with primary or metastatic lung lesions during and after their 4DCT scan (standard-of-care at our institution). A patient-specific 4D model will be developed using the raw 4DCT projections time-correlated with real-time surface monitoring. In addition, before delivering each dose fraction (3 - 5 for lung SBRT), we will acquire three 15s kV fluoroscopic image acquisitions, time-correlated with optical surface mon…
Clinical Trial
Clinical Trial IDNCT03056014Start Date2017-05-01Completion Date2020-06-01PhaseEarly Phase 1Study TypeInterventionalStatusNot yet recruiting
Dietary supplementation with antioxidant vitamins, such as Vitamin C and Vitamin E, reduces malformation rates in embryos of diabetic animals. However, human trials exploring the benefits of these antioxidant vitamins have produced unsatisfactory results in trials designed to alleviating diabetic retinopathy, cardiovascular disease, and preeclampsia in pregnancies. The investigators hypothesize that more potent, and better-targeted antioxidants, such as N-acetylcysteine (NAC) and Polyunsatura…
Clinical Trial
Clinical Trial IDNCT02745548Start Date2017-05-01Completion Date2025-12-01PhaseN/AStudy TypeObservationalStatusRecruiting
In order to better understand radiation-induced lung toxicity, the investigator proposes a novel functional avoidance approach that incorporates central as well as peripheral BSS segments in the treatment planning process in order to quantify and account for their respective radiosensitivities. Specifically, the investigator proposes a systematic study that involves acquiring pre- and post-SAbR high-resolution CT and SPECT V/Q scans from lung cancer patients who receive radiotherapy, followed…
Clinical Trial
Clinical Trial IDNCT02368106Start Date2017-05-01Completion Date2030-12-01PhaseN/AStudy TypeObservational [Patient Registry]StatusNot yet recruiting
This study will create a patient data registry to collect and analyze information on technology usage and outcomes among patients receiving a broad range of relatively new radiation treatments that have become standards of care in our practice. Review of this information will serve as a basis for development of better patient management plans, to inform decisions about acquisition of new technologies, to provide information about quality in our care delivery, and to create a database that wil…