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Publication
PubMed ID28323037Published Date2017-06-28JournalCancer letters, 2017-06-28, Volume 396
We recently reported that PIWI-interacting RNAs likes (piR-Ls) could regulate functions of the interacting phosphorylated proteins (p-Proteins). In addition, except for writers and erasers, functional efficacy of p-Proteins on their readers still remains unknown. We, therefore, reasoned there was a type of sncRNAs which could regulate functional efficacy of p-Proteins. Here, we profiled sncRNAs interacting with phosphorylated -Ser, -Thr and -Tyr residues in 3 HBE and 4 lung SCC cell lines, in…
Clinical Trial
Clinical Trial IDNCT02938923Start Date2017-07-01Completion Date2023-01-01PhasePhase 3Study TypeInterventionalStatusNot yet recruiting
This study is a randomized, controlled multi-center clinical trial comparing the effects of six months of testosterone replacement therapy, with and without supervised exercise training, in frail elderly female hip fracture patients. One third of the participants will receive topical testosterone therapy and a supervised exercise training program; one third will receive topical placebo gel and a supervised exercise training program; one third will receive topical placebo gel and a home exerci…
Publication
PubMed ID28426364Published Date2017-06-07JournalSubstance use & misuse, 2017-06-07, Volume 52
Research on the association between antisocial personality disorder (ASPD) with comorbid mental disorders and sexually transmitted infection (STI)/HIV risk among inmates is scant despite the high prevalence of psychopathology and of STI/HIV in this population.We used baseline data from Project DISRUPT, a cohort study conducted among incarcerated African American men (n = 207), to measure associations between ASPD and STI/HIV risk. We also conducted latent class analyses (LCAs) to identify sub…
Publication
PubMed ID28245933Published Date2017-06-01JournalThe Science of the total environment, 2017-06-01, Volume 587-588
The reliable detection and attribution of changes in vegetation greenness is a prerequisite for the development of strategies for the sustainable management of ecosystems. We conducted a robust trend analysis on remote sensing derived vegetation index time-series matrices to detect significant changes in inter-annual vegetation productivity (greening versus browning) for the entire Himalaya, a biodiverse and ecologically sensitive yet understudied region. The spatial variability in trend was …
Publication
PubMed ID27862257Published Date2017-06-01JournalJournal of cellular biochemistry, 2017-06-01, Volume 118
The study aims to analyze the key signaling pathways in regulating the process of embryonic stem cells (ESCs) differentiation into spermatogonial stem cells (SSCs). Based on RNA Sequencing result, we further explored the specific regulating mechanisms of Hedgehog (HH) signaling in this process. HH signaling was found to be a crucial signaling pathway participating in the differentiation process of ESCs to SSCs. In Retinoic acid (RA) induced in vitro differentiation assay, the expression of tw…
Publication
PubMed ID28316911Published Date2017-06-01JournalPreventive medicine reports, 2017-06-01, Volume 6
An objective of the Built Environment and Active Play (BEAP) Study was to examine whether home built environment, bedroom electronic presence, parental rules and demographics predicted children's sedentary behavior (SB). In 2014, BEAP Study questionnaires were mailed to 2000 parents of children (7-12 years) within the Washington DC area. SB-Duration (hours/day) and SB-Frequency (days/week) were assessed by two questions with multiple subparts relating to SB activity type (e.g. car riding) and…
Publication
PubMed ID28415545Published Date2017-06-01JournalMaterials science & engineering. C, Materials for biological applications, 2017-06-01, Volume 75
Cell-based tissue engineering is promising to create living functional tissues for bone regeneration. The implanted cells should be evenly distributed in the scaffold, be fast-released to the defect and maintain high viability in order to actively participate in the regenerative process. Herein, we report an injectable calcium phosphate cement (CPC) scaffold containing cell-encapsulating hydrogel microfibers with desirable degradability that could deliver cells in a timely manner and maintain…
Publication
PubMed ID28103725Published Date2017-06-01JournalLeukemia & lymphoma, 2017-06-01, Volume 58
A phase 1 study was conducted to determine the dose-limiting toxicities and maximum-tolerated dose (MTD) for bortezomib followed by romidepsin on days 1, 8, and 15 in patients with relapsed/refractory CLL/SLL or B- or T-cell lymphoma. Eighteen treated patients were evaluable for response. The MTD was 1.3 mg/m bortezomib and 10 mg/m romidepsin; median treatment duration was 3 cycles at this dose. The dose-limiting toxicities were grade 3 fatigue, vomiting, and chills. Two patients had partial …
Publication
PubMed ID27403680Published Date2017-06-01JournalHealth communication, 2017-06-01, Volume 32
This research examines the effects of two incidental discrete emotions-fear and anger-on health risk perception (i.e., perceived susceptibility to a health problem) and persuasion. In two experiments, fear and anger were induced before participants were exposed to a public service announcement that advocated sun protection behaviors to prevent skin cancer (Experiment 1) or flossing to prevent gum diseases (Experiment 2). It was found that fearful participants perceived greater susceptibility …
Clinical Trial
Clinical Trial IDNCT02688166Start Date2017-06-01Completion Date2023-12-01PhaseN/AStudy TypeObservationalStatusNot yet recruiting
This research study can help understand how cardiac changes may occur with radiation therapy to the heart based off measurements obtained through biomarkers and cardiac imaging. Researchers plan to perform cardiac imaging and biomarkers for any cardiac injury. Cardiac magnetic resonance imaging (CMR) provides the ability to quantitatively measure cardiac function and injury. The cardiac biomarkers that will be tested are effective in the diagnosis, risk-stratification, and monitoring of heart…